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| Ultimate™ ORFCard for Clone ID IOH62493 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH62493 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC070091.1|Alignment |
| Category: | 64170 |
| Comment: | HS.528581 |
| Related Accession(s): | AL592301|Alignment || AF311287|Alignment || AK024001|Alignment || AK127481|Alignment || BC008877|Alignment || BC035805|Alignment || BC070091|Alignment |
| Gene Name: | caspase recruitment domain family, member 9 |
| Gene Definition: | Homo sapiens, caspase recruitment domain family, member 9, mRNA (cDNA clone MGC:87491 IMAGE:30343821), complete cds. |
| Gene Symbol: | CARD9 |
| Summary: | The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length natures are not clearly defined. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longest isoform (1). |
| mRNA Record: | NM_052813|Alignment |
| GO Category: biological process | regulation of apoptosis (GO:0042981) |
| GO Category: cellular component | intracellular (GO:0005622) |
| GO Category: molecular function | protein binding (GO:0005515) |
| References: | GRIF: 64170 | PUBMED: CARD9 |
| ORF Information | |
| ORF length (bp): | 1101 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI13931|Alignment || CAI13932|Alignment || CAI13933|Alignment || AAG28790|Alignment || BAB14766|Alignment || AAH08877|Alignment || AAH70091|Alignment || Q9H257|Alignment |
| Protein Record: | NP_434700|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 607212 |
| Product: | caspase recruitment domain protein 9 |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 64170 |
| Unigene ID: | Hs.528581 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |