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| Ultimate™ ORFCard for Clone ID IOH6243 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH6243 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC008286.1|Alignment |
| Category: | 1845 |
| Comment: | HS.695925 |
| Related Accession(s): | AK055834|Alignment || AK129822|Alignment || AL049417|Alignment || BC002682|Alignment || BC008286|Alignment || BC035701|Alignment || BT019522|Alignment || BU177084|Alignment || L05147|Alignment |
| Gene Name: | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) |
| Gene Definition: | Homo sapiens, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related), mRNA (cDNA clone IMAGE:3640274), complete cds. |
| Gene Symbol: | DUSP3 |
| Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_004090|Alignment |
| GO Category: biological process | protein amino acid dephosphorylation (GO:0006470) |
| GO Category: molecular function | hydrolase activity (GO:0016787) protein tyrosine phosphatase activity (GO:0004725) protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| References: | GRIF: 1845 | PUBMED: DUSP3 |
| ORF Information | |
| ORF length (bp): | 207 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | AAH02682|Alignment || AAH08286|Alignment || AAH35701|Alignment || AAV38329|Alignment || AAA35777|Alignment || P51452|Alignment |
| Protein Record: | NP_004081|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 600183 |
| Product: | dual specificity phosphatase 3 |
| KEGG Pathway: | MAPK signaling pathway |
| KEGG Pathway: | Phosphatidylinositol signaling system |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 1845 |
| Unigene ID: | Hs.181046 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |