* The ORFCard has links to several external public sites for your convenience.
These links may be occasionally unavailable.
| Ultimate™ ORFCard for Clone ID IOH59402 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH59402 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_006085.3|Alignment |
| Category: | 10380 |
| Comment: | HS.406134 |
| Related Accession(s): | AF125042|Alignment || AJ249339|Alignment || AK021941|Alignment || BC017801|Alignment || BG114910|Alignment || BG428446|Alignment |
| Gene Name: | 3'(2'), 5'-bisphosphate nucleotidase 1 |
| Gene Definition: | Homo sapiens, 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA. |
| Gene Symbol: | BPNT1 |
| Summary: | BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_006085|Alignment |
| GO Category: biological process | neurogenesis (GO:0007399) nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139) |
| GO Category: molecular function | 3'(2'),5'-bisphosphate nucleotidase activity (GO:0008441) hydrolase activity (GO:0016787) inositol or phosphatidylinositol phosphatase activity (GO:0004437) magnesium ion binding (GO:0000287) |
| References: | GRIF: 10380 | PUBMED: BPNT1 |
| ORF Information | |
| ORF length (bp): | 786 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | AAD17329|Alignment || CAB65115|Alignment || AAH17801|Alignment || O95861|Alignment |
| Protein Record: | NP_006076|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 604053 |
| Product: | 3'(2'), 5'-bisphosphate nucleotidase 1 |
| KEGG Pathway: | Sulfur metabolism |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 10380 |
| Unigene ID: | Hs.406134 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |