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| Ultimate™ ORFCard for Clone ID IOH59280 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH59280 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_001001787.1|Alignment |
| Category: | 481 |
| Comment: | HS.291196 |
| Related Accession(s): | AL031726|Alignment || M25160|Alignment || X17161|Alignment || AA514770|Alignment || AY946016|Alignment || BC000006|Alignment || BE223067|Alignment || BM762099|Alignment || BQ934151|Alignment || BT009787|Alignment || CD722755|Alignment || CR407616|Alignment || U16799|Alignment |
| Gene Name: | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| Gene Definition: | Homo sapiens, ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), transcript variant 2, mRNA |
| Gene Symbol: | ATP1B1 |
| Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) represents the longer transcript, and encodes the longer isoform (a). |
| Transcript Variant 2: | This variant (2) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a. |
| mRNA Record: | NM_001001787|Alignment || NM_001677|Alignment |
| GO Category: biological process | potassium ion transport (GO:0006813) sodium ion transport (GO:0006814) transport (GO:0006810) |
| GO Category: cellular component | integral to membrane (GO:0016021) membrane (GO:0016020) sodium:potassium-exchanging ATPase complex (GO:0005890) |
| GO Category: molecular function | sodium:potassium-exchanging ATPase activity (GO:0005391) |
| References: | GRIF: 481 | PUBMED: ATP1B1 |
| ORF Information | |
| ORF length (bp): | 906 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI18888|Alignment || AAA36352|Alignment || CAA35040|Alignment || AAX55911|Alignment || AAH00006|Alignment || AAP88789|Alignment || CAG28544|Alignment || AAC50132|Alignment || P05026|Alignment |
| Protein Record: | NP_001001787|Alignment || NP_001668|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 182330 |
| Product: | Na+/K+ -ATPase beta 1 subunit isoform b |
| KEGG Pathway: | Oxidative phosphorylation |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 481 |
| Unigene ID: | Hs.291196 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |