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| Ultimate™ ORFCard for Clone ID IOH54943 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH54943 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_004092.2|Alignment |
| Category: | 1892 |
| Comment: | HS.76394 |
| Related Accession(s): | AL360181|Alignment || X98126|Alignment || X98129|Alignment || BC008906|Alignment || BC013264|Alignment || BT007123|Alignment || D13900|Alignment |
| Gene Name: | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial |
| Gene Definition: | Homo sapiens, enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (ECHS1), nuclear gene encoding mitochondrial protein, mRNA |
| Gene Symbol: | ECHS1 |
| Summary: | The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_004092|Alignment |
| GO Category: biological process | fatty acid beta-oxidation (GO:0006635) fatty acid metabolism (GO:0006631) generation of precursor metabolites and energy (GO:0006091) lipid metabolism (GO:0006629) metabolism (GO:0008152) |
| GO Category: cellular component | mitochondrion (GO:0005739) |
| GO Category: molecular function | enoyl-CoA hydratase activity (GO:0004300) lyase activity (GO:0016829) |
| References: | GRIF: 1892 | PUBMED: ECHS1 |
| ORF Information | |
| ORF length (bp): | 873 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAH70286|Alignment || CAA66808|Alignment || AAH08906|Alignment || AAP35787|Alignment || BAA03001|Alignment || P30084|Alignment |
| Protein Record: | NP_004083|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 602292 |
| Product: | mitochondrial short-chain enoyl-coenzyme A hydratase 1 precursor |
| KEGG Pathway: | Lysine degradation |
| KEGG Pathway: | Butanoate metabolism |
| KEGG Pathway: | Fatty acid metabolism |
| KEGG Pathway: | Propanoate metabolism |
| KEGG Pathway: | Tryptophan metabolism |
| KEGG Pathway: | beta-Alanine metabolism |
| KEGG Pathway: | Limonene and pinene degradation |
| KEGG Pathway: | Fatty acid biosynthesis (path 2) |
| KEGG Pathway: | Benzoate degradation via CoA ligation |
| KEGG Pathway: | Valine, leucine and isoleucine degradation |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 1892 |
| Unigene ID: | Hs.76394 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |