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| Ultimate™ ORFCard for Clone ID IOH54935 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH54935 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | P46952|Alignment |
| Category: | 23498 |
| Comment: | HS.368805 |
| Related Accession(s): | BC029510|Alignment || CR457063|Alignment || Z29481|Alignment |
| Gene Name: | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene Definition: | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene Symbol: | HAAO |
| Summary: | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_012205|Alignment |
| GO Category: biological process | metabolism (GO:0008152) |
| GO Category: molecular function | 3-hydroxyanthranilate 3,4-dioxygenase activity (GO:0000334) electron transporter activity (GO:0005489) iron ion binding (GO:0005506) oxidoreductase activity (GO:0016491) quinolinate synthetase A activity (GO:0008987) |
| References: | GRIF: 23498 | PUBMED: HAAO |
| ORF Information | |
| ORF length (bp): | 861 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | AAH29510|Alignment || CAG33344|Alignment || CAA82618|Alignment || P46952|Alignment |
| Protein Record: | NP_036337|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 604521 |
| Product: | 3-hydroxyanthranilate 3,4-dioxygenase |
| KEGG Pathway: | Tryptophan metabolism |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 23498 |
| Unigene ID: | Hs.368805 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |