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| Ultimate™ ORFCard for Clone ID IOH5482 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH5482 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_006325.2|Alignment |
| Category: | 5901 |
| Comment: | HS.10842 |
| Related Accession(s): | AB062399|Alignment || AF052578|Alignment || AF054183|Alignment || AF501887|Alignment || BC000852|Alignment || BC004272|Alignment || BC014518|Alignment || BC014901|Alignment || BC016654|Alignment || BC022813|Alignment || BC051908|Alignment || BC072000|Alignment || BT007271|Alignment || CR450347|Alignment || M31469|Alignment |
| Gene Name: | RAN, member RAS oncogene family |
| Gene Definition: | Homo sapiens, RAN, member RAS oncogene family (RAN), mRNA |
| Gene Symbol: | RAN |
| Summary: | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_006325|Alignment |
| GO Category: biological process | DNA metabolism (GO:0006259) RNA-nucleus export (GO:0006405) intracellular protein transport (GO:0006886) mitotic spindle organization and biogenesis (GO:0007052) protein-nucleus export (GO:0006611) regulation of cell cycle (GO:0000074) signal transduction (GO:0007165) small GTPase mediated signal transduction (GO:0007264) |
| GO Category: cellular component | colocalizes_with chromatin (GO:0000785) cytoplasm (GO:0005737) nuclear pore (GO:0005643) nucleus (GO:0005634) |
| GO Category: molecular function | GTP binding (GO:0005525) GTPase activity (GO:0003924) chromatin binding (GO:0003682) protein binding (GO:0005515) |
| References: | GRIF: 5901 | PUBMED: RAN |
| ORF Information | |
| ORF length (bp): | 651 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | BAB93486|Alignment || AAC05840|Alignment || AAC99400|Alignment || AAM15923|Alignment || AAH04272|Alignment || AAH14518|Alignment || AAH14901|Alignment || AAH16654|Alignment || AAH51908|Alignment || AAH72000|Alignment || AAP35935|Alignment || CAG29343|Alignment || AAA36546|Alignment || P62826|Alignment || AAB24940|Alignment |
| Protein Record: | NP_006316|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 601179 |
| Product: | ras-related nuclear protein |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 5901 |
| Unigene ID: | Hs.10842 | Hs.519656 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |