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| Ultimate™ ORFCard for Clone ID IOH45879 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH45879 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_212540.1|Alignment |
| Category: | 1876 |
| Comment: | HS.135465 |
| Related Accession(s): | AJ493061|Alignment || AY083997|Alignment || AY551345|Alignment || AF041381|Alignment || AF059292|Alignment || AF088059|Alignment || AK096197|Alignment || AK223159|Alignment || AK223407|Alignment || AU132447|Alignment || AU142999|Alignment || AY083996|Alignment || AY551346|Alignment || AY551347|Alignment || AY551348|Alignment || AY551349|Alignment || AY551350|Alignment || AY551351|Alignment || BC008348|Alignment || BC062610|Alignment || BQ447956|Alignment |
| Gene Name: | E2F transcription factor 6 |
| Gene Definition: | Homo sapiens, E2F transcription factor 6 (E2F6), transcript variant f, mRNA. |
| Gene Symbol: | E2F6 |
| Summary: | This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant : | This variant (f) uses an alternate 5' splice site in an exon compared to variant a, that causes a frameshift. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1. |
| mRNA Record: | NM_001952|Alignment || NM_198256|Alignment || NM_198257|Alignment || NM_198258|Alignment || NM_198325|Alignment || NM_212540|Alignment |
| GO Category: biological process | negative regulation of transcription from RNA polymerase II promoter (GO:0000122) regulation of cell cycle (GO:0000074) regulation of transcription, DNA-dependent (GO:0006355) transcription (GO:0006350) |
| GO Category: cellular component | nucleus (GO:0005634) transcription factor complex (GO:0005667) |
| GO Category: molecular function | transcription corepressor activity (GO:0003714) transcription factor activity (GO:0003700) |
| References: | GRIF: 1876 | PUBMED: E2F6 |
| ORF Information | |
| ORF length (bp): | 390 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAD37950|Alignment || CAD37951|Alignment || CAD37952|Alignment || AAM10784|Alignment || AAM10785|Alignment || AAT02635|Alignment || AAC14694|Alignment || AAC31426|Alignment || BAD96879|Alignment || BAD97127|Alignment || AAM10783|Alignment || AAT02636|Alignment || AAT02637|Alignment || AAT02638|Alignment || AAT02639|Alignment || AAT02640|Alignment || AAT02641|Alignment || AAH08348|Alignment || O75461|Alignment |
| Protein Record: | NP_001943|Alignment || NP_937987|Alignment || NP_937988|Alignment || NP_937989|Alignment || NP_938084|Alignment || NP_997705|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 602944 |
| Product: | E2F transcription factor 6 isoform 4 |
| KEGG Pathway: | Cell cycle |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 1876 |
| Unigene ID: | Hs.135465 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |