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| Ultimate™ ORFCard for Clone ID IOH45845 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH45845 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_182682.2|Alignment |
| Category: | 7326 |
| Comment: | HS.462035 |
| Related Accession(s): | CQ840929|Alignment || BC002775|Alignment || BC026288|Alignment || BI601205|Alignment || BT007416|Alignment || BT008255|Alignment || BU161770|Alignment || D78514|Alignment |
| Gene Name: | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) |
| Gene Definition: | Homo sapiens, ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) (UBE2G1), transcript variant 2, mRNA. |
| Gene Symbol: | UBE2G1 |
| Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 98-100% sequence identity with the zebrafish, frog, rat and mouse counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longer isoform (1). |
| Transcript Variant 2: | This variant (2) lacks two consecutive exons in the coding region, as compared to variant 1, resulting in an immediate translation termination. Isoform 2 thus has a shorter C-terminus, as compared to isoform 1. |
| mRNA Record: | NM_003342|Alignment || NM_182682|Alignment |
| GO Category: biological process | ubiquitin cycle (GO:0006512) |
| GO Category: molecular function | ligase activity (GO:0016874) ubiquitin conjugating enzyme activity (GO:0004840) ubiquitin-protein ligase activity (GO:0004842) |
| References: | GRIF: 7326 | PUBMED: UBE2G1 |
| ORF Information | |
| ORF length (bp): | 150 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAH05704|Alignment || AAH02775|Alignment || AAH26288|Alignment || AAP36084|Alignment || AAP36947|Alignment || BAA11410|Alignment || P62253|Alignment |
| Protein Record: | NP_003333|Alignment || NP_872623|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 601569 |
| Product: | ubiquitin-conjugating enzyme E2G 1 isoform 2 |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 7326 |
| Unigene ID: | Hs.462035 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |