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| Ultimate™ ORFCard for Clone ID IOH45813 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH45813 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_198324.1|Alignment |
| Category: | 1431 |
| Comment: | HS.430606 |
| Related Accession(s): | CQ782923|Alignment || AF047042|Alignment || AF053631|Alignment || AK074956|Alignment || AK095856|Alignment || AK098177|Alignment || AL713477|Alignment || BC000105|Alignment || BC010106|Alignment || BC072016|Alignment || BI258893|Alignment || BI553413|Alignment || BT007414|Alignment || BX640838|Alignment || CB990178|Alignment |
| Gene Name: | citrate synthase |
| Gene Definition: | Homo sapiens, citrate synthase (CS), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA |
| Gene Symbol: | CS |
| Summary: | The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longer isoform (a). |
| Transcript Variant 2: | This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a. |
| mRNA Record: | NM_004077|Alignment || NM_198324|Alignment |
| GO Category: biological process | tricarboxylic acid cycle (GO:0006099) |
| GO Category: cellular component | cytoplasm (GO:0005737) mitochondrion (GO:0005739) |
| GO Category: molecular function | citrate (Si)-synthase activity (GO:0004108) citrate (Si)-synthase activity (GO:0004108) transferase activity (GO:0016740) |
| References: | GRIF: 1431 | PUBMED: CS |
| ORF Information | |
| ORF length (bp): | 1203 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAF86150|Alignment || AAC25560|Alignment || AAQ13428|Alignment || BAC11314|Alignment || AAH00105|Alignment || AAH10106|Alignment || AAH72016|Alignment || AAP36082|Alignment || CAE45911|Alignment || O75390|Alignment |
| Protein Record: | NP_004068|Alignment || NP_938083|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 118950 |
| Product: | citrate synthase precursor, isoform b |
| KEGG Pathway: | Citrate cycle (TCA cycle) |
| KEGG Pathway: | Glyoxylate and dicarboxylate metabolism |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 1431 |
| Unigene ID: | Hs.430606 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |