* The ORFCard has links to several external public sites for your convenience.
These links may be occasionally unavailable.
| Ultimate™ ORFCard for Clone ID IOH3323 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH3323 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | ENST00000361450 |
| Category: | 28227 |
| Comment: | HS.124942 |
| Related Accession(s): | AF215840|Alignment || AL954664|Alignment || AF135016|Alignment || AF155098|Alignment || AI248426|Alignment || AL157501|Alignment || BC009032|Alignment || BC011180|Alignment || BC063429|Alignment || BF530463|Alignment || BI828434|Alignment || BK000521|Alignment || BM676246|Alignment || BU845905|Alignment || CB218994|Alignment |
| Gene Name: | protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta |
| Gene Definition: | protein phosphatase 2, regulatory subunit B'', beta [Source:HGNC Symbol;Acc:13417] |
| Gene Symbol: | PPP2R3B |
| Summary: | Protein phosphatase 2A is a heterotrimeric serine/threonine phosphatase implicated in many cellular processes. The core enzyme of PP2A comprises a catalytic subunit (C) and a constant regulatory subunit (A). The core enzyme associates with one of three B regulatory subunits, which are encoded by different genes. The B subunits are thought to determine the substrate specificity and the subcellular localization of the enzyme. This gene encodes the regulatory subunit B''. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) represents the longer transcript and encodes the longer isoform (1). |
| Transcript Variant 2: | This variant (2) lacks several exons and differs in the 5' end-region compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1. |
| mRNA Record: | NM_013239|Alignment || NM_199326|Alignment |
| GO Category: biological process | DNA replication initiation (GO:0006270) cell cycle arrest (GO:0007050) protein amino acid dephosphorylation (GO:0006470) |
| GO Category: cellular component | nucleus (GO:0005634) protein phosphatase type 2A complex (GO:0000159) |
| GO Category: molecular function | calcium ion binding (GO:0005509) hydrolase activity (GO:0016787) phosphoprotein phosphatase activity (GO:0004721) protein binding (GO:0005515) protein phosphatase type 2A activity (GO:0000158) protein phosphatase type 2A regulator activity (GO:0008601) |
| References: | GRIF: 28227 | PUBMED: PPP2R3B |
| ORF Information | |
| ORF length (bp): | 531 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI41962|Alignment || CAI41963|Alignment || AAD38515|Alignment || AAD42864|Alignment || CAB75680|Alignment || AAH09032|Alignment || AAH11180|Alignment || AAH63429|Alignment || DAA00385|Alignment || Q9Y5P8|Alignment |
| Protein Record: | NP_037371|Alignment || NP_955358|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 300339 |
| Product: | protein phosphatase 2, regulatory subunit B'' isoform 2 |
| KEGG Pathway: | Tight junction |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 28227 |
| Unigene ID: | Hs.124942 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |