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| Ultimate™ ORFCard for Clone ID IOH3295 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH3295 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_000558.3|Alignment |
| Category: | 3039 |
| Comment: | HS.449630 |
| Related Accession(s): | AE006462|Alignment || AF230076|Alignment || AF351127|Alignment || AF363956|Alignment || AF525460|Alignment || AF536204|Alignment || AY178732|Alignment || AY178733|Alignment || AY183122|Alignment || AY196787|Alignment || AY261678|Alignment || AY298911|Alignment || AY605050|Alignment || J00153|Alignment || J00157|Alignment || M22813|Alignment || M22814|Alignment || V00491|Alignment || V00492|Alignment || Z84721|Alignment || AF105974|Alignment || AF281258|Alignment || AF349571|Alignment || AK223392|Alignment |
| Gene Name: | hemoglobin, alpha 1 |
| Gene Definition: | Homo sapiens, hemoglobin, alpha 1 (HBA1), mRNA |
| Gene Symbol: | HBA1 |
| Summary: | The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes the following five loci: 5'- zeta - pseudozeta - pseudoalpha-1 - alpha-2 - alpha-1 -3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1 respectively; some nondeletion alpha thalassemias have also been reported. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_000558|Alignment |
| GO Category: biological process | oxygen transport (GO:0015671) transport (GO:0006810) |
| GO Category: cellular component | hemoglobin complex (GO:0005833) |
| GO Category: molecular function | heme binding (GO:0020037) oxygen binding (GO:0019825) |
| References: | GRIF: 3039 | PUBMED: HBA1 |
| ORF Information | |
| ORF length (bp): | 429 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | AAK61215|Alignment || AAK61216|Alignment || AAF72612|Alignment || AAK15770|Alignment || AAK50822|Alignment || AAM83102|Alignment || AAN04486|Alignment || AAO22463|Alignment || AAO22464|Alignment || AAO24131|Alignment || AAO42516|Alignment || AAP44005|Alignment || AAP56246|Alignment || AAT36649|Alignment || AAB59408|Alignment || AAA52632|Alignment || AAA52631|Alignment || AAA52631|Alignment || CAA23750|Alignment || CAA23751|Alignment || CAB06555|Alignment || AAC97373|Alignment || AAF90195|Alignment || AAK37554|Alignment || BAD97112|Alignment |
| Protein Record: | NP_000549|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 141800 |
| Product: | alpha 1 globin |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 3039 |
| Unigene ID: | Hs.449630 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |