* The ORFCard has links to several external public sites for your convenience.
These links may be occasionally unavailable.
| Ultimate™ ORFCard for Clone ID IOH2920 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH2920 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC000903.2|Alignment |
| Category: | 3148 |
| Comment: | HS.434953 |
| Related Accession(s): | M83665|Alignment || AU129699|Alignment || BC000903|Alignment || BC001063|Alignment || BT019782|Alignment || BT019783|Alignment || X62534|Alignment || Z17240|Alignment |
| Gene Name: | high-mobility group box 2 |
| Gene Definition: | Homo sapiens, high-mobility group box 2, mRNA |
| Gene Symbol: | HMGB2 |
| Summary: | This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_002129|Alignment |
| GO Category: biological process | DNA repair (GO:0006281) DNA replication (GO:0006260) DNA unwinding (GO:0006268) base-excision repair, DNA ligation (GO:0006288) establishment and/or maintenance of chromatin architecture (GO:0006325) nucleosome assembly (GO:0006334) regulation of transcription from RNA polymerase II promoter (GO:0006357) |
| GO Category: cellular component | chromatin (GO:0000785) condensed chromosome (GO:0000793) nuclear chromosome (GO:0000228) perinuclear region (GO:0048471) |
| GO Category: molecular function | DNA bending activity (GO:0008301) double-stranded DNA binding (GO:0003690) single-stranded DNA binding (GO:0003697) transcription factor activity (GO:0003700) |
| References: | GRIF: 3148 | PUBMED: HMGB2 |
| ORF Information | |
| ORF length (bp): | 588 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | AAA58659|Alignment || AAH00903|Alignment || AAH01063|Alignment || AAV38585|Alignment || AAV38586|Alignment || CAA44395|Alignment || CAA78938|Alignment || P26583|Alignment |
| Protein Record: | NP_002120|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 163906 |
| Product: | high-mobility group box 2 |
| Human Proto Array: | ProtoArray Human Protein Microarray nc v1.0 |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 3148 |
| Unigene ID: | Hs.434953 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |