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| Ultimate™ ORFCard for Clone ID IOH28109 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH28109 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_176786.1|Alignment |
| Category: | 3581 |
| Comment: | HS.406228 |
| Related Accession(s): | AJ271736|Alignment || AY071830|Alignment || L39064|Alignment || S71420|Alignment || BC025298|Alignment || BC051337|Alignment || M84747|Alignment || S71404|Alignment |
| Gene Name: | interleukin 9 receptor |
| Gene Definition: | Homo sapiens, interleukin 9 receptor (IL9R), transcript variant 2, mRNA |
| Gene Symbol: | IL9R |
| Summary: | The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longer isoform (1). |
| Transcript Variant 2: | This variant (2) has multiple differences in the coding region, compared to variant 1, which results in a frameshift. The resulting predicted protein (isoform 2) has distinct N- and C-termini, internal differences, and is shorter than isoform 1. |
| mRNA Record: | NM_002186|Alignment || NM_176786|Alignment |
| GO Category: biological process | cell proliferation (GO:0008283) signal transduction (GO:0007165) |
| GO Category: cellular component | extracellular space (GO:0005615) integral to plasma membrane (GO:0005887) membrane (GO:0016020) |
| GO Category: molecular function | hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896) interleukin-9 receptor activity (GO:0004919) receptor activity (GO:0004872) |
| References: | GRIF: 3581 | PUBMED: IL9R |
| ORF Information | |
| ORF length (bp): | 999 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAB96817|Alignment || AAL55435|Alignment || AAC29513|Alignment || AAD14081|Alignment || AAH51337|Alignment || AAA58679|Alignment || AAB30844|Alignment || Q01113|Alignment |
| Protein Record: | NP_002177|Alignment || NP_789743|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 300007 |
| Product: | interleukin 9 receptor isoform 2 |
| KEGG Pathway: | Jak-STAT signaling pathway |
| KEGG Pathway: | Cytokine-cytokine receptor interaction |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 3581 |
| Unigene ID: | Hs.406228 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |