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| Ultimate™ ORFCard for Clone ID IOH26983 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH26983 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC046095.1|Alignment |
| Category: | 9590 |
| Comment: | HS.371240 |
| Related Accession(s): | AL033392|Alignment || AL356535|Alignment || AL590413|Alignment || AB003476|Alignment || AF001504|Alignment || AF086250|Alignment || BC000188|Alignment || BC015830|Alignment || BC022814|Alignment || BC046095|Alignment || BC047728|Alignment || CR749527|Alignment || CR936604|Alignment || M96322|Alignment || U81607|Alignment |
| Gene Name: | A kinase (PRKA) anchor protein (gravin) 12 |
| Gene Definition: | Homo sapiens, A kinase (PRKA) anchor protein (gravin) 12, mRNA (cDNA clone IMAGE:6190455), complete cds. |
| Gene Symbol: | AKAP12 |
| Summary: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longer isoform (1), compared to variant 2. |
| Transcript Variant 2: | This variant (2) has an alternate 5' segment, compared to variant 1, that results in a distinct 5'UTR and 5' coding region. Isoform 2 has a distinct and shorter N-terminus compared to isoform 1. |
| mRNA Record: | NM_005100|Alignment || NM_144497|Alignment |
| GO Category: biological process | G-protein coupled receptor protein signaling pathway (GO:0007186) protein targeting (GO:0006605) signal transduction (GO:0007165) |
| GO Category: cellular component | cytoplasm (GO:0005737) |
| GO Category: molecular function | protein binding (GO:0005515) protein kinase A binding (GO:0051018) |
| References: | GRIF: 9590 | PUBMED: AKAP12 |
| ORF Information | |
| ORF length (bp): | 423 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI20467|Alignment || CAI20468|Alignment || CAI16151|Alignment || CAI13590|Alignment || CAI13591|Alignment || BAA19927|Alignment || AAB58938|Alignment || AAH46095|Alignment || AAH47728|Alignment || CAH18338|Alignment || CAI56750|Alignment || AAA35931|Alignment || AAC51366|Alignment || Q02952|Alignment |
| Protein Record: | NP_005091|Alignment || NP_653080|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 604698 |
| Product: | A-kinase anchor protein 12 isoform 2 |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 9590 |
| Unigene ID: | Hs.371240 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |