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| Ultimate™ ORFCard for Clone ID IOH26970 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH26970 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC046147.1|Alignment |
| Category: | 8243 |
| Comment: | HS.211602 |
| Related Accession(s): | AL161779|Alignment || Z97054|Alignment || AK055575|Alignment || AK056308|Alignment || AK091458|Alignment || BC064368|Alignment || BC080185|Alignment || BQ232418|Alignment || BX640922|Alignment || D17084|Alignment || D17256|Alignment || D80000|Alignment || S78271|Alignment |
| Gene Name: | SMC1 structural maintenance of chromosomes 1-like 1 (yeast) |
| Gene Definition: | Homo sapiens, Similar to SMC (structural maintenance of chromosomes1)-like 1 (S. cerevisiae), mRNA,complete cds. |
| Gene Symbol: | SMC1L1 |
| Summary: | Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_006306|Alignment |
| GO Category: biological process | DNA damage response, signal transduction (GO:0042770) DNA repair (GO:0006281) cell cycle (GO:0007049) cell cycle checkpoint (GO:0000075) chromosome organization and biogenesis (GO:0051276) chromosome segregation (GO:0007059) cytokinesis (GO:0000910) meiosis (GO:0007126) mitotic sister chromatid cohesion (GO:0007064) mitotic spindle organization and biogenesis (GO:0007052) response to radiation (GO:0009314) |
| GO Category: cellular component | chromosome (GO:0005694) cohesin core heterodimer (GO:0008280) condensed nuclear chromosome (GO:0000794) kinetochore (GO:0000776) nucleus (GO:0005634) |
| GO Category: molecular function | ATP binding (GO:0005524) ATPase activity (GO:0016887) chromatin binding (GO:0003682) microtubule motor activity (GO:0003777) protein binding (GO:0005515) protein heterodimerization activity (GO:0046982) |
| References: | GRIF: 8243 | PUBMED: SMC1L1 |
| ORF Information | |
| ORF length (bp): | 453 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI42089|Alignment || CAI42646|Alignment || AAH64368|Alignment || AAH80185|Alignment || CAE45960|Alignment || BAA11495|Alignment || AAB34405|Alignment || Q14683|Alignment |
| Protein Record: | NP_006297|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 300040 |
| Product: | SMC1 structural maintenance of chromosomes 1-like 1 |
| KEGG Pathway: | Cell cycle |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 8243 |
| Unigene ID: | Hs.211602 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |