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| Ultimate™ ORFCard for Clone ID IOH14304 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH14304 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | NM_006120.2|Alignment |
| Category: | 3108 |
| Comment: | HS.351279 |
| Related Accession(s): | AL645941|Alignment || AL662845|Alignment || AL935042|Alignment || U04877|Alignment || U04878|Alignment || X76775|Alignment || X87344|Alignment || Z96104|Alignment || BC011447|Alignment || BC026279|Alignment || CR450324|Alignment || X62744|Alignment |
| Gene Name: | major histocompatibility complex, class II, DM alpha |
| Gene Definition: | Homo sapiens, major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA |
| Gene Symbol: | HLA-DMA |
| Summary: | HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_006120|Alignment |
| GO Category: biological process | antigen presentation, exogenous antigen (GO:0019884) antigen processing, exogenous antigen via MHC class II (GO:0019886) detection of pest, pathogen or parasite (GO:0009596) immune response (GO:0006955) |
| GO Category: cellular component | integral to membrane (GO:0016021) membrane (GO:0016020) |
| GO Category: molecular function | MHC class II receptor activity (GO:0045012) MHC class II receptor activity (GO:0045012) protein binding (GO:0005515) |
| References: | GRIF: 3108 | PUBMED: HLA-DMA |
| ORF Information | |
| ORF length (bp): | 786 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI18109|Alignment || CAI17491|Alignment || CAI18686|Alignment || CAI18687|Alignment || AAA56993|Alignment || AAA56994|Alignment || CAA54169|Alignment || CAA54170|Alignment || CAA60781|Alignment || AAH11447|Alignment || AAH26279|Alignment || CAG29320|Alignment || CAA44606|Alignment || P28067|Alignment |
| Protein Record: | NP_006111|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 142855 |
| Product: | major histocompatibility complex, class II, DM alpha precursor |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 3108 |
| Unigene ID: | Hs.351279 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |