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| Ultimate™ ORFCard for Clone ID IOH11353 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH11353 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | BC019928.1|Alignment |
| Category: | 22859 |
| Comment: | HS.654658 |
| Related Accession(s): | AB065919|Alignment || AB020628|Alignment || AF307079|Alignment || AK022001|Alignment || BC002974|Alignment || BC007587|Alignment || BC013275|Alignment || BC019928|Alignment || BC028296|Alignment || BC052627|Alignment || BC072445|Alignment |
| Gene Name: | latrophilin 1 |
| Gene Definition: | Homo sapiens, latrophilin 1, mRNA (cDNA clone IMAGE:3870835), complete cds. |
| Gene Symbol: | LPHN1 |
| Summary: | This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) encodes the longer isoform (1). |
| Transcript Variant 2: | This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1. |
| mRNA Record: | NM_001008701|Alignment || NM_014921|Alignment |
| GO Category: biological process | neuropeptide signaling pathway (GO:0007218) signal transduction (GO:0007165) |
| GO Category: cellular component | integral to membrane (GO:0016021) membrane (GO:0016020) |
| GO Category: molecular function | G-protein coupled receptor activity (GO:0004930) latrotoxin receptor activity (GO:0016524) receptor activity (GO:0004872) sugar binding (GO:0005529) |
| References: | GRIF: 22859 | PUBMED: LPHN1 |
| ORF Information | |
| ORF length (bp): | 606 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | BAC06134|Alignment || BAA74844|Alignment || AAG27461|Alignment || BAB13950|Alignment || AAH02974|Alignment || AAH07587|Alignment || AAH19928|Alignment || O94910|Alignment |
| Protein Record: | NP_001008701|Alignment || NP_055736|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| Product: | latrophilin 1 isoform 2 precursor |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 22859 |
| Unigene ID: | Hs.94229 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |