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| Ultimate™ ORFCard for Clone ID IOH10841 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH10841 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | ENST00000348993 |
| Category: | 598 |
| Comment: | HS.516966 |
| Related Accession(s): | AL117381|Alignment || AL160175|Alignment || U72398|Alignment || BC019307|Alignment || BT007208|Alignment || BX647525|Alignment || CR936637|Alignment || Z23115|Alignment || Z23116|Alignment |
| Gene Name: | BCL2-like 1 |
| Gene Definition: | Homo sapiens, SCAN domain-containing protein 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9GZW5] |
| Gene Symbol: | BCL2L1 |
| Summary: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| Transcript Variant 1: | This variant (1) is also known as bcl-xL. It encodes a longer isoform (1). |
| Transcript Variant 2: | This variant (2) is also known as bcl-xS or bcl-x beta. It lacks an exon within the coding region when compared to variant 1. The translation remains in-frame, and results in a shorter isoform (2) that lacks an internal segment, as compared to isoform 1. |
| mRNA Record: | NM_001191|Alignment || NM_138578|Alignment |
| GO Category: biological process | anti-apoptosis (GO:0006916) apoptotic mitochondrial changes (GO:0008637) negative regulation of survival gene product activity (GO:0008634) regulation of apoptosis (GO:0042981) |
| GO Category: cellular component | integral to membrane (GO:0016021) membrane (GO:0016020) mitochondrial outer membrane (GO:0005741) mitochondrion (GO:0005739) |
| GO Category: molecular function | protein binding (GO:0005515) |
| References: | GRIF: 598 | PUBMED: BCL2L1 |
| ORF Information | |
| ORF length (bp): | 459 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAI23025|Alignment || CAI23026|Alignment || CAI23027|Alignment || CAC10003|Alignment || CAI12811|Alignment || CAI12812|Alignment || CAI12813|Alignment || CAI12814|Alignment || CAI12815|Alignment || AAB17354|Alignment || AAH19307|Alignment || AAP35872|Alignment || CAI56777|Alignment || CAA80661|Alignment || CAA80662|Alignment || Q07817|Alignment |
| Protein Record: | NP_001182|Alignment || NP_612815|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 600039 |
| Product: | BCL2-like 1 isoform 2 |
| KEGG Pathway: | Apoptosis |
| KEGG Pathway: | Jak-STAT signaling pathway |
| KEGG Pathway: | Neurodegenerative Disorders |
| KEGG Pathway: | Amyotrophic lateral sclerosis (ALS) |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 598 |
| Unigene ID: | Hs.516966 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
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Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |