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| Ultimate™ ORFCard for Clone ID IOH10280 | |
|---|---|
| Gene Information | |
| Clone ID: | IOH10280 |
| Organism: | Homo sapiens |
| Matching Nucleotide Accession: | ENST00000379704 |
| Category: | 573 |
| Comment: | HS.377484 |
| Related Accession(s): | AL161445|Alignment || AL356472|Alignment || AF022224|Alignment || AF116273|Alignment || AK096038|Alignment || AK222749|Alignment || BC001936|Alignment || BC014774|Alignment || U46917|Alignment || Z35491|Alignment |
| Gene Name: | BCL2-associated athanogene |
| Gene Definition: | BCL2-associated athanogene [Source:HGNC Symbol;Acc:937] |
| Gene Symbol: | BAG1 |
| Summary: | The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site. |
| Expression: | Sage Tag Expression || Virtual Northern || Digital Expression Profile |
| mRNA Record: | NM_004323|Alignment |
| GO Category: biological process | anti-apoptosis (GO:0006916) apoptosis (GO:0006915) cell surface receptor linked signal transduction (GO:0007166) protein folding (GO:0006457) protein modification (GO:0006464) |
| GO Category: cellular component | cytoplasm (GO:0005737) |
| GO Category: molecular function | receptor signaling protein activity (GO:0005057) unfolded protein binding (GO:0051082) |
| References: | GRIF: 573 | PUBMED: BAG1 |
| ORF Information | |
| ORF length (bp): | 825 |
| Sequence: | Nucleotide || Peptide || Translation || Quality Scores || Quality Scores with Sequence |
| Clone Information | |
| Collection Name: | Ultimate ORF Clones |
| Collection Type: | ORF Gateway™ Entry |
| Vector Name: | pENTR(tm)221 |
| Vector Antibiotic: | Kanamycin |
| Host Name: | E.coli |
| Protein | |
| Protein Accession: | CAH72516|Alignment || CAH72517|Alignment || CAH72518|Alignment || CAH72520|Alignment || CAH72741|Alignment || CAH72742|Alignment || CAH72743|Alignment || AAC34258|Alignment || AAD25045|Alignment || BAD96469|Alignment || AAH01936|Alignment || AAH14774|Alignment || AAD11467|Alignment || CAA84624|Alignment || Q99933|Alignment |
| Protein Record: | NP_004314|Alignment |
| Physical Properties: | (aa) || 0.0 (MW) || 0.0 (pI) |
| Protease Digestion: | Trypsin | Lys-C | Arg-C | Asp-N | V8-bicarb | V8-phosph | Chymotrypsin | CNBr |
| Predicted Secondary Structure: | View Secondary Structure |
| Protein Model Search: | Swiss-Model BLAST |
| OMIM: | 601497 |
| Product: | BCL2-associated athanogene isoform 1L |
| SNP Information | |
| SNP: | All rs in gene region | rs in coding region only | rs with heterozygosity only |
| SNP Map to: | Protein |
| Genomic Link | |
| LocusLink ID: | 573 |
| Unigene ID: | Hs.377484 |
| Genome Alignment: | Map to Human Genome using BLAT || Map to Ensembl Genome Browser |
|
Disclaimer: Invitrogen™ Corporation provides an evolving clone collection where each gene represented is identified as containing a complete open reading frame, based on a dynamic source of bioinformatic information contained within GenBank. GenBank is a genetic sequence database, which contains an annotated collection of all publicly available DNA sequences. Ultimate™ ORF Clones are typically derived from cDNA clones believed to contain a complete open reading frame, according to the most current GenBank update. Please note, subsequent GenBank updates may show some of these cDNA clones to contain a partial sequence, a non-coding sequence or other artifacts. Quarterly, Invitrogen™ Corporation will update the Ultimate™ ORF Clone Collection, by adding, deleting, or modifying the bioinformatic information to more accurately reflect the most current scientific information associated with each of the clones represented in the collection. It is highly recommended that the purchaser carefully evaluate the ORF clone sequence prior to purchase. It is the purchaser’s responsibility to check whether the sequence associated with any particular clone meets his/her scientific requirement prior to purchase. Invitrogen makes no warranties, express or implied, that the manufacture, use, importation, or sale of the gene contained within any Ultimate™ ORF clone will not infringe any third party intellectual property right. | |